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OGG1 (8-oxoguanine DNA glycosylase), Human

OGG1, also known as 8-oxoguanine glycosylase, is the primary enzyme responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG) , and is also a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen species (ROS). This protein is a DNA glycosylase enzyme involved in base excision repair. Additionally, OGG1 has a beta lyase activity that nicks DNA 3' to the lesion.
No. Size Price Qty Status
C01147-5UG 5 ug $108.00 Inquiry
C01147-20UG 20 ug $268.00 Inquiry
C01147-100UG 100 ug $528.00 Inquiry
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Sequence: 
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTP
DELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFP
SLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWH
IAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQCRHAQEPPAKRRKGSKGPEG with polyhistidine tag
at the C-terminus

UnitProt ID:
O15527
 
Source:
Escherichia coli

Endotoxin Test:
<0.1 EU per 1 μg of the protein by the LAL method.
 
Purity:
>98% as determined by SDS-PAGE analysis.

Form:
Lyophilized

Storage Buffer:
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution:
It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

Stability & Storage​:
This product is stable after storage at:
• -20°C for 12 months in lyophilized state from date of receipt.
• -20°C or -80°C for 1 month under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.

Shipping Conditions:
Blue ice